Benzonatate addictive

Dosage for Benzonatate. Adults and Children over 10 years of age: Usual dose is one 100 mg or 200 mg capsule three times a day as needed for cough. If necessary to control cough, up to 600 mg daily in three divided doses may be given. Benzonatate should be swallowed whole.

Benzonatate addictive. Addict. Narc., Add. 1. Page 40. 166. N. B. EDDY AND ... Benzonatate, 2,5,8,11,14,17 ,20,23,26-nonoxaocta ... Addiction (1955) Wld Hlth Org., techn. Rep. Ser ...

Hypersensitivity to benzonatate, related compounds, or any component of the formulation. Dosage and Administration Dosing: Adult. Cough: Oral: 100 to 200 mg 3 times/day as needed for cough (maximum single dose: 200 mg; maximum dose: 600 mg/day) Dosing: Geriatric. Refer to adult dosing.

Poison Center Hotline: 1-800-222-1222 The Maryland Poison Center’s Monthly Update: News, Advances, Information Subscribe to ToxTidbits and read past issues at www.mdpoison.comJun 26, 2023 ... I also hated benzonatate, and people rarely say it helps their cough. ... Especially fucking benzonatate, how many ... addictive qualities with this ...No, Benzonatate does not show up on a drug test. Benzonatate is a commonly used antitussive agent and it is non-narcotic in nature. It is neither structurally similar to narcotics nor produces similar effects, which is why it does not cause euphoria or addiction. This is why standard drug tests don’t really focus on this medication and it is ...Benzonatate is a cough suppressant. When taking benzonatate, be sure to swallow the capsule whole and drink a full glass of water. Letting the capsules dissolve in your mouth and throat will cause ...Dec 12, 2022 · Benzonatate is a nonnarcotic antitussive medication first approved by the US Food and Drug Administration (FDA) in 1958 for the symptomatic relief of cough in patients ≥10 years old. 1 Known risks described in the benzonatate product labeling include oropharyngeal anesthesia that may lead to choking and airway compromise, and convulsions that may lead to central nervous system depression. 1 ...

Benzonatate This information from Lexicomp explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to call your healthcare provider. Brand Names: US Tessalon Perles [DSC] What is this drug used for? It is used to relieve coughing. What do I need to tell my doctor BEFORE I take Benzonatate (Tessalon) is a non-opioid antitussive that has been available for over 50 years. Structurally similar to ester-type local anesthetics, its mechanism includes sodium channel blockade and anesthesia of pulmonary stretch receptors. Benzonatate’s onset of action is approximately 15 to 20 minutes with effects lasting three to eight ...WebMD publishes a long list of common prescription medications used to treat the symptoms of cough. They are identified by generic name and common brand names. At the top of the We...... addiction risk when abused, such as DXM. ... Are over-the-counter drugs addictive? Certain OTC ... However, one option is benzonatate (brand name: Tessalon Perles). Benzonatate is a cough suppressant that relieves cough. It works by calming your cough reflex. Common brand names for this medication include Tessalon®, Perles® and Zonatuss®. Talk to a healthcare provider if your symptoms don’t improve or if they get worse while taking this medication. Benzonatate (Tessalon) is a prescription medication for managing a cough. While it is usually well tolerated, it has a few potential side effects. Common benzonatate side effects include dizziness, drowsiness, and headache. Constipation and nausea can happen, too. Most side effects are generally mild, can be managed at home, and go …For many years, parents have wondered about the negative effects of video games on their children’s health — and even into adulthood, partners might see the harmful ways video game...Tylenol ( acetaminophen) is a safe pain-reliever to take with benzonatate. There is no known interaction between them. Interestingly enough, benzonatate has very few drug interactions. Most drug references don't list it having any. Nevertheless, benzonatate can cause mild drowsiness and sedation in some individuals, so there …

Benzonatate can cause central nervous problems such as dizziness, hallucinations, confusion, or extreme drowsiness. Call a doctor or other healthcare professional if benzonatate is causing serious CNS impairment. Medical help may also be necessary if experiencing side effects like chills or chest numbness. 8.Living with addiction can be a challenging and overwhelming experience. It affects not only the individual struggling with substance abuse but also their loved ones. For those seek...Feb 9, 2018 · Benzonatate comes in the form of a capsule and a perle (smaller capsule) you take by mouth. This medication needs to be swallowed whole. You shouldn’t break, chew, cut, or crush this drug. This ... 1 drugs are known to interact with benzonatate. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.No, benzonatate (generic for Tessalon) will not loosen mucus. It acts only as a cough suppressant. If you are looking for a medication to help clear congestion and mucus, a drug like guaifenesin would be more appropriate. Additionally, to treat sinus pressure, a nasal decongestant like pseudoephedrine would be an option that is often …

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Benzonatate, a non-narcotic oral antitussive agent, is 2, 5, 8, 11, 14, 17, 20, 23, 26-nonaoxaoctacosan-28-yl p- (butylamino) benzoate; with a molecular weight of 603.7. Each soft gelatin capsule, for oral administration, contains 100 mg, 150 mg or 200 mg of benzonatate USP. Benzonatate Capsules, USP also contain the following inactive ...Benzonatate is a cough suppressant that relieves cough. It works by calming your cough reflex. Common brand names for this medication include Tessalon®, Perles® and Zonatuss®. Talk to a healthcare provider if your symptoms don’t improve or if they get worse while taking this medication.If you or someone you love is struggling with psychiatric illness, addiction, domestic violence, or other problems that pertain to mental health and overall well-being, know that h...Alcoholics Anonymous, also known as AA, is a 12-step recovery program for people who have been diagnosed with alcohol addiction or feel that they have a problem with drinking and w...Benzonatate capsules, USP, a non-narcotic oral antitussive agent, is 2, 5, 8, 11, 14, 17, 20, 23, 26- onaoxaoctacosan-28-ylp- (butylamino) benzoate; with a molecular weight of 603.7.Each ... CLINICAL PHARMACOLOGY. Benzonatate capsules act peripherally by anesthetizing the stretch receptors located in the respiratory passages, …Dec 5, 2023 · Mixing benzonatate 200 mg and alcohol may lead to an increased risk of side effects from alcohol and benzonatate. Benzonatate may cause various side effects, but the most common side effects may include: Sedation. Headache. Dizziness. Itching. Skin rash. Constipation. Nausea.

ANS: 2 The antitussive agent benzonatate will suppress the cough reflex response in the brain. Antitussive agents (cough suppressants) like benzonatate act by suppressing the cough center in the brain. It will not stop the cough completely, but should decrease its frequency and suppress the severe spasms that prevent adequate rest at night.Adults and Children over 10 years of age: Usual dose is one 100 mg or 200 mg capsule three times a day as needed for cough. If necessary to control cough, up to 600 mg daily in three divided doses ... HOW SUPPLIED. Benzonatate Capsules USP, 200 mg are clear yellow, oval-shaped softgel capsules imprinted with “PC15” and are supplied as ...Adults and Children over 10: Usual dose is one 100 mg or 200 mg capsule t.i.d. as required. If necessary, up to 600 mg daily may be given. Benzonatate capsules USP 100 mg are available for oral administration as a clear, colorless to pale yellow oil in a clear, yellow softgel shell imprinted "A" in white ink.The health benefits of quitting are pretty obvious but the addictive nature of nicotine makes it difficult. Do you gradually cut down the number of cigarettes you smoke in a day? T...[12-14-2010] The U.S. Food and Drug Administration (FDA) is warning the public that accidental ingestion of benzonatate by children under the age of 10 years can result in death from overdose....Benzonatate is a nonnarcotic antitussive medication first approved by the US Food and Drug Administration (FDA) in 1958 for the symptomatic relief of cough in patients ≥10 years old. 1 Known risks described in the benzonatate product labeling include oropharyngeal anesthesia that may lead to choking and airway compromise, and …Opiate Addiction · Opiates · Opiod Deaths · Opiods · Opioid · Organophosphate · Oseltamivir · Outreach · Overdose · O...Benzonatate is a non-narcotic oral antitussive (cough suppressant) drug which works by anesthetizing the tissues of the lungs and pleura responsible for the cough reflex. It is chemically related to other ester anesthetics such as procaine. It has an anesthetic (numbing) action similar to that of benzocaine and “numbs” the stretch sensors ...Benzonatate is a nonnarcotic antitussive medication first approved by the US Food and Drug Administration (FDA) in 1958 for the symptomatic relief of cough in patients ≥10 years old. 1 Known risks described in the benzonatate product labeling include oropharyngeal anesthesia that may lead to choking and airway compromise, and convulsions that may lead to central nervous system depression. 1 ...

Jan 23, 2023 · Abstract. Objective: To review the available literature regarding the treatment effects and efficacy of benzonatate needed to better inform patients, providers, and regulators evaluating its role in modern medical therapies. Data sources: Comprehensive literature searches were conducted in PubMed, Embase (Elsevier), Cochrane Library, and Scopus ...

Release of Benzonatate from the capsule in the mouth can produce a temporary local anesthesia of the oral mucosa and choking could occur. If numbness or tingling of the tongue, mouth, throat, or face occurs, refrain from oral ingestion of food or liquids until the numbness has resolved. If the symptoms worsen or persist, seek …Unlike opioid-based cough suppressants, benzonatate offers relief without the risk of addiction or sedation, making it a preferred choice for many healthcare providers. What is Benzonatate? Benzonatate is a non-narcotic cough suppressant that helps relieve coughing. It works by numbing the throat and lungs, reducing the urge to …Benzonatate should not be taken with certain other medications, including sedatives, tranquilizers, narcotic pain relievers, muscle relaxants, sleeping pills, and other cough and cold medicines. Taking Benzonatate with these drugs can cause serious side effects, such as increased drowsiness and difficulty breathing. Benzonatate is a cough suppressant that relieves cough. It works by calming your cough reflex. Common brand names for this medication include Tessalon®, Perles® and Zonatuss®. Talk to a healthcare provider if your symptoms don’t improve or if they get worse while taking this medication. Editor’s Note: If you or someone you know is living with an opioid addiction or another substance use disorder, know that help is available. Narcan, also known as Naloxone, is an F...Alcoholics Anonymous (AA) is a fellowship of individuals who share their experience, strength, and hope with each other so that they may learn to live with addiction and help other...Benzonatate (Tessalon). Imipenem. INH. Lidocaine. Seizures (continued). Lithium ... A diabetic drug addict on linezolid (Zyvox) for 28 days for MRSA sepsis is ...Benzonatate should not be taken with certain other medications, including sedatives, tranquilizers, narcotic pain relievers, muscle relaxants, sleeping pills, and other cough and cold medicines. Taking Benzonatate with these drugs can cause serious side effects, such as increased drowsiness and difficulty breathing.Benzonatate should not be taken with certain other medications, including sedatives, tranquilizers, narcotic pain relievers, muscle relaxants, sleeping pills, and other cough and cold medicines. Taking Benzonatate with these drugs can cause serious side effects, such as increased drowsiness and difficulty breathing.Hypersensitivity to benzonatate, related compounds, or any component of the formulation. Dosage and Administration Dosing: Adult. Cough: Oral: 100 to 200 mg 3 times/day as needed for cough (maximum single dose: 200 mg; maximum dose: 600 mg/day) Dosing: Geriatric. Refer to adult dosing.

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Although benzonatate (Tesslon Perles) is an NaV blocker commonly prescribed to treat cough, like lidocaine it has low potency and the NaV blockade actually achieved is likely incomplete as well as transient. A non-selective NaV blocker, GSK2339345, failed in a clinical trial for chronic idiopathic cough.Benzonatate (Tessalon) is a prescription medication for managing a cough. While it is usually well tolerated, it has a few potential side effects. Common benzonatate side effects include dizziness, drowsiness, and headache. Constipation and nausea can happen, too. Most side effects are generally mild, can be managed at home, and go … Addictive Potential: Benzonatate is not considered addictive, while Benzodiazepines have a higher potential for dependence and addiction. Side Effects : Benzonatate may cause mild side effects such as dizziness and drowsiness, while Benzodiazepines may cause more significant side effects such as sedation, confusion, and memory problems. Benzonatate is a commonly prescribed cough suppressant with over 3 million prescriptions per year in the US in 2016. Benzonatate shares structural similarities with other local anesthetics such as benzocaine and tetracaine, and alleviates cough through numbing the peripheral stretch receptors in the respiratory system. 1 Calls to poison …Benzonatate is a cough suppressant. When taking benzonatate, be sure to swallow the capsule whole and drink a full glass of water. Letting the capsules dissolve in your mouth and throat will cause ...An internal conflict is a problem faced by a character inside his or her own mind. Some examples of internal conflicts are competing desires or priorities, tough decisions, and ove...DESCRIPTION. Benzonatate, a non-narcotic oral antitussive agent, is 2, 5, 8, 11, 14, 17, 20, 23, 26-nonaoxaoctacosan-28-yl p (butylamino) benzoate; with a molecular weight of 603.7. Each soft gelatin capsule, for oral administration, contains 100 mg or 200 mg benzonatate USP. In addition, each capsule contains the following inactive ingredients ...Benzonatate, sold under the brand name Tessalon, is prescribed to treat coughs caused by colds or the flu. It is not approved for children younger than 10 years old. The findings, published in the ...Dextromethorphan. Dextromethorphan is a dissociative agent, similar to ketamine and phencyclidine. Dextromethorphan contains an alkylated amine adjacent to a cyclohexane ring; a structural moiety common to the dissociative agents.8 Dextromethorphan has equal antitussive effects as codeine but does not possess analgesic or addictive properties.22Nov 15, 2022 · Benzonatate is a nonnarcotic antitussive medication first approved by the US Food and Drug Administration (FDA) in 1958 for the symptomatic relief of cough in patients ≥10 years old. 1 Known risks described in the benzonatate product labeling include oropharyngeal anesthesia that may lead to choking and airway compromise, and convulsions that may lead to central nervous system depression. 1 ... Benzonatate is a unique antitussive medication with sodium channel-blocking properties that may cause severe, life-threatening toxicity in overdose, including coma, seizures, ventricular dysrhythmias, and cardiac arrest. Prescribing healthcare workers, dispensing pharmacists, patients, and caregivers should be aware of this toxicity and the new ... ….

binding to the analgesic/addictive receptors in the ... of the antitussive effect of benzonatate ... Cardiac arrest with residual blindness after overdose of ...When you take too much—intentionally or by accident—it causes a high, like some illicit drugs. Some types are riskier than others, especially if you have teens or young children at home. Here’s what you need to know to treat that nasty cold and stay safe. Is cough syrup addictive? It depends.The Bottom Line. Benzonatate is an anesthetic drug and cough suppressant. When benzonatate capsules are swallowed, the medication acts directly on the lungs to reduce coughing. Benzonatate is only approved for use in individuals 10 years of age and older. Younger children who take benzonatate may experience serious toxicity or even death.Although benzonatate (Tesslon Perles) is an NaV blocker commonly prescribed to treat cough, like lidocaine it has low potency and the NaV blockade actually achieved is likely incomplete as well as transient. A non-selective NaV blocker, GSK2339345, failed in a clinical trial for chronic idiopathic cough.Benzocaine is a local anesthetic used in pain control management, and it is in the ester local anesthetic class of medications. This activity describes the indications, action, and contraindications for benzocaine as a valuable agent in managing pain control. This activity will highlight the mechanism of action, adverse event profile, and other key factors (e.g., off-label uses, dosing ...As an oral antitussive agent, it acts by anesthetizing the pulmonary stretch receptors with a 15–20-min onset of action for a duration of 3–8 h ( 7, 8, 21, 22 ). Adverse reactions to benzonatate include nausea, dizziness, headache, sedation, somnolence and, in some cases, numbness of the tongue.Benzonatate - Clinical Pharmacology. Benzonatate acts peripherally by anesthetizing the stretch receptors located in the respiratory passages, lungs, and pleura by dampening their activity and thereby reducing the cough reflex at its source. It begins to act within 15 to 20 minutes and its effect lasts for 3 to 8 hours.It is not addictive so there isn’t a limit on the number of days you can take it. However, if you are still coughing after seven days of taking this medication you should let your healthcare provider know. “Benzonatate is typically prescribed for around a week or so,” says Dr. Hsu. Benzonatate addictive, Benzonatate (Tessalon) is a prescription medication for managing a cough. While it is usually well tolerated, it has a few potential side effects. Common benzonatate side effects include dizziness, drowsiness, and headache. Constipation and nausea can happen, too. Most side effects are generally mild, can be managed at home, and go away when ..., Useless for any other cough. When you've cleared the virus but your lungs are healing and sensitive to stretch, and taking a deep breath can trigger a coughing jag that makes you nearly puke, but there's no sputum no fever no nasal congestion - try tessalon. It works by anesthetizing stretch receptors in the lungs. Reply reply., Benzonatate, USP 200 mg. Benzonatate capsules USP also contain: bloom gelatin, glycerin, purified water, medium chain triglycerides, lecithin, isopropyl alcohol, nitrogen. 200 mg capsules also contain D&C Yellow No. 10. Each capsule also contains black iron oxide, propylene glycol, hypromellose as imprinting ink., Benzocaine is a topical anesthetic contained in some marketed over-the-counter (OTC) oral drug products intended to relieve pain from a variety of conditions such as sore throats, canker sores ..., The health benefits of quitting are pretty obvious but the addictive nature of nicotine makes it difficult. Do you gradually cut down the number of cigarettes you smoke in a day? T..., Sodium benzonatate is a nonopioid antitussive that is a long-chain polyglycol derivative of procaine. When applied orally, it provides rapid topical anesthesia suitable for awake oral intubation. 174. Cocaine, in solutions from 1% to 10%, provides excellent topical anesthesia. It has the advantage of providing vasoconstriction because of its ..., We study 15,328 people who have side effects when taking Benzonatate. Drug abuse and dependence is reported by 36 (0.23%) of them. People who are more likely to have Drug abuse and dependence are male, 40-49 old, also take Meloxicam and have Pain. The phase IV clinical study analyzes which people take Benzonatate and have Drug abuse and dependence., Nov 15, 2022 · Benzonatate is a nonnarcotic antitussive medication first approved by the US Food and Drug Administration (FDA) in 1958 for the symptomatic relief of cough in patients ≥10 years old. 1 Known risks described in the benzonatate product labeling include oropharyngeal anesthesia that may lead to choking and airway compromise, and convulsions that may lead to central nervous system depression. 1 ... , Opiate Addiction · Opiates · Opiod Deaths · Opiods · Opioid · Organophosphate · Oseltamivir · Outreach · Overdose · O..., Benzonatate capsules, USP, a non-narcotic oral antitussive agent, is 2, 5, 8, 11, 14, 17, 20, 23, 26- onaoxaoctacosan-28-ylp- (butylamino) benzoate; with a molecular weight of 603.7.Each ... CLINICAL PHARMACOLOGY. Benzonatate capsules act peripherally by anesthetizing the stretch receptors located in the respiratory passages, lungs, and pleura ..., Benzonatate is used to relieve coughs due to colds or influenza (flu). It is not to be used for chronic cough that occurs with smoking, asthma, or emphysema or when there is an unusually large amount of mucus or phlegm with the cough., Benzonatate is an antitussive (the clinical term for a cough suppressant). “By anesthetizing the nerves in these receptors in the lungs, it helps decrease the mechanism of cough or the sensation ..., Citation 22 It can be considered a safer alternative for use in patients with addiction to or dependence on other antitussives with high abuse potential. Benzonatate (Tessalon Perles; Pfizer, New York, NY, USA) is a non-narcotic butylamine chemically related to ester anesthetics., Benzonatate has an average rating of 4.0 out of 10 from a total of 776 ratings on Drugs.com. 30% of reviewers reported a positive effect, while 62% reported a negative effect. Tessalon Perles has an average rating of 5.1 out of 10 from a total of 179 ratings on Drugs.com. 42% of reviewers reported a positive effect, while 48% reported a ..., Release of Benzonatate from the capsule in the mouth can produce a temporary local anesthesia of the oral mucosa and choking could occur. If numbness or tingling of the tongue, mouth, throat, or face occurs, refrain from oral ingestion of food or liquids until the numbness has resolved. If the symptoms worsen or persist, seek …, May 28, 2021 · Benzonatate can cause central nervous problems such as dizziness, hallucinations, confusion, or extreme drowsiness. Call a doctor or other healthcare professional if benzonatate is causing serious CNS impairment. Medical help may also be necessary if experiencing side effects like chills or chest numbness. 8. , buspirone. tricyclic antidepressants. propranolol. pregabalin. hydroxyzine pamoate. Note that not all of the medications listed above are first-line for all anxiety disorders, and some are only ..., WebMD publishes a long list of common prescription medications used to treat the symptoms of cough. They are identified by generic name and common brand names. At the top of the We..., Benzonatate capsules should be given to a pregnant woman only if clearly needed. Nursing Mothers: It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk caution should be exercised when benzonatate capsules are administered to a nursing woman. Carcinogenesis, Mutagenesis, …, ANS: 2 The antitussive agent benzonatate will suppress the cough reflex response in the brain. Antitussive agents (cough suppressants) like benzonatate act by suppressing the cough center in the brain. It will not stop the cough completely, but should decrease its frequency and suppress the severe spasms that prevent adequate rest at night., Benzonatate is a prescription cough suppressant approved for adults and children over the age of 10. The recommended dosage is 100 mg to 200 mg up to three times a day as needed for cough. Be sure to swallow the capsule whole — don’t hold it in your mouth or break it open. You shouldn’t take more than 600 mg of benzonatate in a day., Adults and Children over 10 years of age: Usual dose is one 100 mg or 200 mg capsule three times a day as needed for cough. If necessary to control cough, up to 600 mg daily in three divided doses ... HOW SUPPLIED. Benzonatate Capsules USP, 200 mg are clear yellow, oval-shaped softgel capsules imprinted with “PC15” and are supplied as ..., Jan 4, 2023 · Benzonatate (Tessalon) is a non-opioid antitussive that has been available for over 50 years. Structurally similar to ester-type local anesthetics, its mechanism includes sodium channel blockade and anesthesia of pulmonary stretch receptors. Benzonatate’s onset of action is approximately 15 to 20 minutes with effects lasting three to eight ... , Benzonatate (Tessalon) is a prescription medication for managing a cough. While it is usually well tolerated, it has a few potential side effects. Common benzonatate side effects include dizziness, drowsiness, and headache. Constipation and nausea can happen, too. Most side effects are generally mild, can be managed at home, and go away when ..., Benzonatate comes as a liquid-filled capsule and a capsule to take by mouth. It is usually taken three times a day as needed. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take benzonatate exactly as directed., It is available in 100 or 200 mg capsules, with a maximum daily dose of 600 mg. Benzonatate contains nine ethoxy units, bears molecular resemblance to the local anesthetic tetracaine, and is thought to act similar to a local anesthetic. (3, 4, 5) Structure of Benzonatate: Image Courtesy of Wikimedia Commons. Chemically known as 4- (butylamino ..., Introduction. Benzonatate (Fig 1A), an orally administrated non-narcotic cough suppressant first approved in 1958 [], is chemically related to amino ester local anesthetics such as tetracaine.Cough suppression is mediated by inhibition of pulmonary stretch receptors, possibly through inhibition of voltage-gated sodium channels, …, Benzonatate has been on the market for over a half century and is widely prescribed. In 2010, there was a review published by the National Poison Center Database System (2000–2006) that included 2173 patients who had ingested benzonatate alone, of which the mean age was 20 years and 30% of the patients were younger than 6 years of age [ 3 ]., Alcoholism is a health condition that affects millions of people around the world. If you or someone you know is living with alcohol addiction, it’s important to get help. One way ..., If your healthcare provider prescribes benzonatate, you should follow the instructions on your medicine label. Prescribers may dose this medication differently for different people. Typically, patients take 100 mg to 200 mg of benzonatate up to three times per day, or every 8 hours. The maximum dose of benzonatate is 600 mg per day., Nov. 15, 2022, 2:08 PM PST / Source: TODAY. By Sarah Jacoby. The Food and Drug Administration is warning that a lesser-known prescription cough medication, called benzonatate, is finding its way ..., Benzonatate (Tessalon Perles) is a cough suppressant. It's used to relieve cough in people ages 10 years and older. Benzonatate (Tessalon Perles) is taken by mouth three times a day as needed. Possible side effects of …, Read this chapter of Davis's Drug Guide for Rehabilitation Professionals online now, exclusively on F.A. Davis PT Collection. F.A. Davis PT Collection is a subscription-based resource from McGraw Hill that features trusted content from the best minds in PT.