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Apr 1, 2019 · A high frequency of Eomes + T-bet low CD8 + T cells was associated with poor response to induction chemotherapy and shorter overall survival in AML patients. These findings have significant clinical implications as they not only identify a predictive and prognostic biomarker for AML, but they also provide an important target for effective ...

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Despite the central role of T-bet and Eomes in differentiation fate decisions, little is known about their influence on human CD8+ T cell responses . Here, we show that human bulk and virus-specific CD8+ T cells expressing …